Although, there is not a published study on donor fertility/ability to conceive after donating, we have no reason to believe that being a donor will compromise a woman’s future fertility.
When we are born, women have all of the eggs they are going to have for a lifetime. We naturally ‘lose’ these eggs as we grow up. We see evidence of this when we hit puberty and begin our menstrual cycle. During a typical menstrual cycle, a woman’s pituitary gland sends out hormones that mature only one of the hundreds of eggs that are released every month. During an IVF cycle, the medications we use assist the hormones and allow more eggs to mature. This ensures we have more eggs to fertilize in the lab than just one. Through this process, we maximize the odds of success by encouraging the hormones to work a little harder to accomplish what they ordinarily do naturally.
IRH did a very small pilot study a few years ago that asked 100 ex-donors a series of questions focused on how many months of unprotected intercourse it took them to conceive after having been a donor. The results were very encouraging. It was a small study, and entirely retrospective, but it suggested that the expected time to conception for ex-donors was not any different than women in the general population.